Lorincz Lab
Our lab studies the role of histone modifications, DNA methylation, and chromatin remodelling factors in transcriptional regulation of genes and retroelements during mouse development using next-generation sequencing technologies.
We are located at the Life Science Institute, University of British Columbia, Vancouver, Canada.
Chromatin marks feature diverse interactions, sometimes promoting the acquisition of new marks and other times precluding them. NSD1 lays down H3K36me2, and this mark in particular seems to promote DNAme on the one hand and prevent PRC2 from depositing H3K27me3 on the other.
From Interplay between chromatin marks in development and disease.
see Publications or Scopus for complete list of publications from the Lorincz Lab