Lorincz Lab

Our lab studies the role of histone modifications, DNA methylation, and chromatin remodelling factors in transcriptional regulation of genes and retroelements during mouse development using next-generation sequencing technologies.

We are located at the Life Science Institute, University of British Columbia, Vancouver, Canada.

LTR Retrotransposon Evolutionary Age

Evolutionary colonization time of selected LTR families, with respect to the phylogeny of catarrhine primates, rodents and glires. Novel LTR integration events provide a substrate for evolution, acting as enhancers or promoters in specific cell types with epigenetic effects cascading throughout development.

From LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation.