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Lorincz Lab

Our lab studies the role of histone modifications, DNA methylation, and chromatin remodelling factors in transcriptional regulation of genes and retroelements during mouse development using next-generation sequencing technologies.

We are located at the Life Science Institute, University of British Columbia, Vancouver, Canada.

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Density plot depicting the distribution of DNAme in mouse blastocyst, parthenogenetic blastocyst, inner cell mass (ICM) (C57BL/6×DBA F1 cross) and ICM (maternal allele).

From Brind'Amour J, Kobayashi H, Richard Albert J, et al. LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation. Nat Commun. 2018.