Home

Lorincz Lab

Our lab studies the role of histone modifications, DNA methylation, and chromatin remodelling factors in transcriptional regulation of genes and retroelements during mouse development using next-generation sequencing technologies.

We are located at the Life Science Institute, University of British Columbia, Vancouver, Canada.

Screen Shot 2019-04-08 at 2.10.08 PM

Density plot depicting the distribution of DNAme in mouse blastocyst, parthenogenetic blastocyst, inner cell mass (ICM) (C57BL/6×DBA F1 cross) and ICM (maternal allele).

From Brind'Amour J, Kobayashi H, Richard Albert J, et al. LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation. Nat Commun. 2018.

RSS Recent Publications

  • ZFP57 regulation of transposable elements and gene expression within and beyond imprinted domains.
    Related Articles ZFP57 regulation of transposable elements and gene expression within and beyond imprinted domains. Epigenetics Chromatin. 2019 08 09;12(1):49 Authors: Shi H, Strogantsev R, Takahashi N, Kazachenka A, Lorincz MC, Hemberger M, Ferguson-Smith AC Abstract BACKGROUND: KRAB zinc finger proteins (KZFPs) represent one of the largest families of DNA-binding proteins in vertebrate genomes and […]